Mesenchymal to epithelial transition

Across TCGA cell cohorts, RNA activity of the Mesenchymal to epithelial transition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM62, PTPN12, and GPR35, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM62 grouped by Mesenchymal to epithelial transition-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIM62 →	-0.716	-0.971	.002	.002	3	4
BONE	PTPN12 →	-1.290	-1.470	<.001	.004	3	4
LIVER	GPR35 →	+2.560	+0.944	.004	.006	3	4
SOFT_TISSUE	TIMM10 →	-0.900	-0.884	<.001	.003	3	3
SOFT_TISSUE	SUCLG2 →	+0.974	+1.166	.001	.008	3	3
OESOPHAGUS	SLC25A6 →	+1.192	+0.570	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM62 by Mesenchymal to epithelial transition activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →