Mesenchymal to epithelial transition

Across TCGA cell cohorts, RNA activity of the Mesenchymal to epithelial transition pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBG1, SAMD9, and H2BC13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal to epithelial transition activity versus CRYBG1 in BONE (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CRYBG1 →	+2.944	+0.389	<.001	<.001	3	5
BONE	SAMD9 →	+1.690	+0.389	.002	<.001	3	5
KIDNEY	H2BC13 →	-0.577	-0.389	.007	.002	3	4
BONE	ATP10D →	+1.546	+0.389	<.001	<.001	3	4
BONE	B2M →	+1.859	+0.389	.003	<.001	3	4
PANCREAS	MANBA →	+1.139	+0.425	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060231 vs CRYBG1 — BONE

Explore this scatter interactively →