Male mating behavior

Across TCGA patient cohorts, RNA activity of the Male mating behavior pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF3C5, SMC2, and HDAC2_S394, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male mating behavior activity versus GTF3C5 in HNSC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GTF3C5 →	+0.245	+0.080	<.001	.005	3	7
LSCC	SMC2 →	+0.346	+0.063	<.001	<.001	3	6
LSCC	HDAC2_S394 →	+0.290	+0.064	<.001	<.001	3	6
LSCC	GTF3C1 →	+0.258	+0.072	<.001	<.001	3	6
LSCC	EHMT1 →	+0.194	+0.050	.007	.009	3	6
GBM	HDAC2 →	+0.315	+0.089	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060179 vs GTF3C5 — HNSC

Explore this scatter interactively →