Male mating behavior

Across TCGA pan-cancer cohorts, RNA activity of the Male mating behavior pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Male mating behavior pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and PAAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, COAD, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.857	0.950	<.001	51	view →
COAD	DFS	Median	III,IV	0.660	0.398	.002	35	view →
ESCA	OS	Quartile	II,III,IV	0.595	0.853	.002	33	view →
PAAD	DFS	Median	All	0.400	0.198	<.001	28	view →
MESO	OS	Tertile	II,III,IV	0.212	0.458	.017	19	view →
READ	DFS	Tertile	IV	0.386	0.852	.020	9	view →
LUAD	OS	Median	All	0.636	0.721	.016	8	view →
KIRC	DFS	Quartile	II,III,IV	0.729	0.828	.025	7	view →
GBM	OS	Median	All	0.447	0.228	.007	6	view →
UVM	OS	Median	All	1.000	0.801	.024	6	view →
BRCA	OS	Median	IV	0.587	0.220	.032	6	view →
SCLC	DFS	Quartile	II,III,IV	0.792	0.437	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0060179–KIRP (DFS)

Open the KIRP breakdown →