Platelet dense granule organization

Across TCGA patient cohorts, RNA activity of the Platelet dense granule organization pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA1, PIK3CG, and ALPK1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet dense granule organization activity versus ABCA1 in UVM (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ABCA1 →	+1.581	+0.047	<.001	<.001	3	34
TGCT	PIK3CG →	+1.099	+0.040	<.001	<.001	3	33
TGCT	ALPK1 →	+0.834	+0.028	<.001	.001	3	33
DLBC	NFAT5 →	+1.743	+0.069	<.001	<.001	3	32
DLBC	HPS5 →	+1.195	+0.069	<.001	<.001	3	32
DLBC	DYNC1LI2 →	+1.672	+0.069	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060155 vs ABCA1 — UVM

Explore this scatter interactively →