Positive regulation of post-transcriptional gene silencing

Across TCGA patient cohorts, RNA activity of the Positive regulation of post-transcriptional gene silencing pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLSTP1, LHX4, and TSSK3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of post-transcriptional gene silencing activity versus DLSTP1 in LAML (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	DLSTP1 →	+0.748	+0.060	<.001	<.001	3	32
LAML	LHX4 →	+0.667	+0.055	<.001	.001	2	32
THYM	TSSK3 →	+0.467	+0.082	<.001	<.001	3	31
DLBC	KMT2D →	+1.311	+0.087	<.001	<.001	3	31
THYM	JMJD7-PLA2G4B →	+1.331	+0.093	<.001	<.001	3	31
THYM	PKD1P3 →	+1.089	+0.097	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060148 vs DLSTP1 — LAML

Explore this scatter interactively →