Maternal process involved in parturition

pathway activity — cross-omics
GO:0060137Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Maternal process involved in parturition pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APBB1IP, ATG3, and CASP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCAPBB1IP →+1.121+0.341<.001<.00134
HNSCATG3 →+0.597+0.281<.001.00133
HNSCCASP1 →+0.969+0.248.002.00233
HNSCFMNL1 →+1.136+0.316<.001.00133
HNSCNCKAP1L →+1.231+0.315<.001.00133
HNSCPTAFR_S339 →+0.975+0.271.003.00424
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration