Maternal process involved in parturition

Across TCGA pan-cancer cohorts, RNA activity of the Maternal process involved in parturition pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Maternal process involved in parturition pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and UVM, show the opposite pattern, with higher activity associated with better survival.

MESO, ACC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.284	0.529	<.001	121	view →
ACC	DFS	Quartile	All	0.782	0.144	<.001	66	view →
LGG	DFS	Median	All	0.659	0.813	<.001	49	view →
UVM	DFS	Tertile	II,III,IV	0.675	0.362	.004	42	view →
THCA	DFS	Tertile	II,III,IV	0.962	0.749	<.001	33	view →
BRCA	DFS	Median	IV	0.692	0.282	.001	31	view →
UCEC	DFS	Tertile	IV	0.198	0.657	.013	20	view →
KIRC	DFS	Tertile	III,IV	0.729	0.438	.007	18	view →
THYM	OS	Quartile	All	0.675	0.959	.007	17	view →
BLCA	DFS	Tertile	All	0.439	0.295	.025	16	view →
SCLC	DFS	Quartile	All	0.301	0.850	.006	15	view →
LUAD	DFS	Quartile	III,IV	0.482	0.802	.024	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0060137–MESO (DFS)

Open the MESO breakdown →