Maternal process involved in parturition

Across TCGA cell cohorts, RNA activity of the Maternal process involved in parturition pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEST, EDF1, and METTL7A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEST grouped by Maternal process involved in parturition-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MEST →	+6.576	+1.386	<.001	.002	3	3
SOFT_TISSUE	EDF1 →	+0.661	+1.443	.009	.008	3	3
URINARY_TRACT	METTL7A →	+4.059	+0.406	.005	.006	3	3
OESOPHAGUS	MTFR1L →	-0.617	-0.654	.005	.006	3	3
BLOOD_Myeloma	NEFH →	-0.110	-1.411	.006	<.001	3	3
PANCREAS	RBFA →	-0.924	-0.964	.006	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEST by Maternal process involved in parturition activity — SOFT_TISSUE

Explore this box plot interactively →