Prepulse inhibition

Across TCGA patient cohorts, RNA activity of the Prepulse inhibition pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EXOC7, UFC1, and GSDMD_S252, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prepulse inhibition activity versus EXOC7 in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EXOC7 →	+0.172	+0.058	.001	.001	3	4
PDAC	UFC1 →	-0.526	-0.077	.001	.003	3	4
PDAC	GSDMD_S252 →	-0.488	-0.060	.002	.003	3	4
LSCC	MAP4K5 →	+0.205	+0.059	.002	.008	3	4
CCRCC	GMPR2 →	+0.328	+0.064	<.001	.001	3	4
BRCA	SEC24B →	+0.153	+0.056	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060134 vs EXOC7 — BRCA

Explore this scatter interactively →