Positive regulation of growth hormone secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of growth hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC33A1, CNRIP1, and NES_S842, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of growth hormone secretion activity versus SLC33A1 in CCRCC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC33A1 →	+0.461	+0.065	<.001	<.001	3	5
CCRCC	CNRIP1 →	-0.410	-0.076	<.001	<.001	3	5
GBM	NES_S842 →	-0.535	-0.092	.001	<.001	3	5
OV	RMDN3 →	+0.350	+0.100	.004	.002	3	4
COAD	RSU1 →	-0.265	-0.061	.003	<.001	3	4
CCRCC	SEPTIN2 →	-0.167	-0.074	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060124 vs SLC33A1 — CCRCC

Explore this scatter interactively →