Positive regulation of growth hormone secretion

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of growth hormone secretion pathway differs between tumor and matched normal tissue in 8 of the 18 cancer types tested.

The strongest signal is observed in stomach adenocarcinoma (STAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as STAD and THCA, show the opposite pattern, with lower activity in tumor tissue.

STAD, BRCA, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
STAD	Male	II,III,IV	−0.132	<.001	6	view →
BRCA	All	II,III,IV	+0.073	<.001	6	view →
LUSC	Male	All	+0.074	<.001	5	view →
THCA	Female	All	−0.028	.034	3	view →
COAD	All	All	−0.042	.019	2	view →
KICH	All	All	+0.058	.024	1	view →
LIHC	Female	All	−0.054	.009	1	view →
KIRP	All	III,IV	−0.038	.048	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 8 strongest of 8 lineages.

GO:0060124–STAD

Open the STAD breakdown →