Positive regulation of growth hormone secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of growth hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASD2, NRSN1, and GPC5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of growth hormone secretion activity versus RASD2 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RASD2 →	+0.862	+0.415	<.001	<.001	3	2
GBM	NRSN1 →	+1.102	+0.439	<.001	<.001	3	2
PDAC	GPC5 →	+0.522	+1.151	.002	.002	3	2
PDAC	PRRT1 →	+0.189	+1.013	.003	.009	3	2
GBM	FAM153CP →	+0.328	+0.428	<.001	<.001	3	2
GBM	CBLN1 →	+0.560	+0.282	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060124 vs RASD2 — GBM

Explore this scatter interactively →