Inner ear receptor cell stereocilium organization

Across TCGA patient cohorts, RNA activity of the Inner ear receptor cell stereocilium organization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX11, C5AR1, and SHARPIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear receptor cell stereocilium organization activity versus STX11 in LUAD (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STX11 →	-0.286	-0.370	.009	.006	3	4
LUAD	C5AR1 →	-0.460	-0.465	.005	.004	3	4
PDAC	SHARPIN →	+0.290	+0.464	<.001	.007	3	4
COAD	CLDN4 →	+0.544	+0.707	.001	.001	3	4
LUAD	MYADM →	-0.422	-0.467	.004	.004	3	3
PDAC	FNDC11 →	+0.327	+0.435	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060122 vs STX11 — LUAD

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