Inner ear receptor cell stereocilium organization

Across TCGA cell cohorts, RNA activity of the Inner ear receptor cell stereocilium organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTL8C, COMMD7, and LGALS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear receptor cell stereocilium organization activity versus RTL8C in LARGE_INTESTINE (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RTL8C →	-4.067	-0.944	<.001	.005	2	6
OVARY	COMMD7 →	-0.755	-0.986	.001	.005	3	4
STOMACH	LGALS1 →	-3.560	-1.249	.004	.004	3	4
BLOOD_Leukemia	PLCH1 →	+2.005	+0.156	.001	.002	3	4
STOMACH	YIPF5 →	-0.912	-1.285	.005	.006	3	4
STOMACH	PRXL2C →	-0.807	-1.045	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060122 vs RTL8C — LARGE_INTESTINE

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