Inner ear receptor cell stereocilium organization

Across TCGA cell cohorts, RNA activity of the Inner ear receptor cell stereocilium organization pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT88, SOD1, and PLS1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear receptor cell stereocilium organization activity versus IFT88 in LIVER (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IFT88 →	+1.586	+1.728	<.001	<.001	3	14
BREAST	SOD1 →	+1.271	+1.117	<.001	<.001	2	13
PANCREAS	PLS1 →	+1.429	+1.552	<.001	<.001	3	10
BLOOD_Lymphoma	NCLN →	-0.764	-0.523	<.001	.004	3	10
STOMACH	ANP32A →	+1.598	+1.345	.001	<.001	3	9
OESOPHAGUS	PTMA →	+1.627	+1.205	.004	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060122 vs IFT88 — LIVER

Explore this scatter interactively →