Relaxation of vascular associated smooth muscle

Across TCGA patient cohorts, RNA activity of the Relaxation of vascular associated smooth muscle pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SVIL, TPM2, and FKBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of vascular associated smooth muscle activity versus SVIL in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SVIL →	+0.725	+0.104	<.001	<.001	3	8
UCEC	TPM2 →	+1.213	+0.098	<.001	<.001	3	8
COAD	FKBP7 →	+0.694	+0.046	<.001	.004	3	8
UCEC	GUCY1A1 →	+0.646	+0.115	<.001	<.001	3	8
GBM	MYL9 →	+0.881	+0.108	<.001	<.001	3	8
GBM	RCN3 →	+0.932	+0.086	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060087 vs SVIL — GBM

Explore this scatter interactively →