Relaxation of vascular associated smooth muscle

Across TCGA patient cohorts, RNA activity of the Relaxation of vascular associated smooth muscle pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKG1, C7, and PODN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of vascular associated smooth muscle activity versus PRKG1 in UCEC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+0.849	+1.013	.002	<.001	3	9
COAD	C7 →	+2.025	+0.222	<.001	<.001	3	8
LUAD	PODN →	+0.911	+0.520	<.001	<.001	3	8
GBM	SEPTIN4 →	+1.442	+0.593	<.001	<.001	3	7
COAD	LMOD1 →	+1.528	+0.178	<.001	.001	3	7
COAD	JAM3 →	+0.735	+0.190	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060087 vs PRKG1 — UCEC

Explore this scatter interactively →