Regulation of postsynaptic membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGCC_S91, TNS2_S120, and RPL12_S38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic membrane potential activity versus RGCC_S91 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RGCC_S91 →	+1.293	+0.932	<.001	<.001	3	5
LSCC	TNS2_S120 →	+0.618	+0.742	<.001	<.001	3	5
LSCC	RPL12_S38 →	-0.723	-0.831	<.001	<.001	3	4
BRCA	SMC2 →	-0.527	-0.739	<.001	<.001	3	4
LSCC	SMC4 →	-0.642	-0.947	<.001	<.001	3	4
OV	TADA3_S298 →	-0.926	-0.829	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060078 vs RGCC_S91 — OV

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