Synapse maturation

Across TCGA patient cohorts, RNA activity of the Synapse maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITSN1_T1144, STXBP1, and UBAC1_S332, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse maturation activity versus ITSN1_T1144 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITSN1_T1144 →	+0.423	+0.064	.001	.008	3	5
GBM	STXBP1 →	+0.860	+0.068	<.001	<.001	3	4
GBM	UBAC1_S332 →	+0.431	+0.067	.006	.006	3	4
LSCC	PPP4R3A →	+0.298	+0.051	.001	<.001	3	4
HNSC	TBC1D5 →	-0.190	-0.036	<.001	.007	3	4
GBM	DAB2_S723 →	-0.584	-0.070	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060074 vs ITSN1_T1144 — GBM

Explore this scatter interactively →