Synapse maturation

Across TCGA patient cohorts, RNA activity of the Synapse maturation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP3B2, SLC6A17, and CDKN1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse maturation activity versus AP3B2 in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP3B2 →	+0.367	+0.328	.006	.004	3	4
GBM	SLC6A17 →	+1.361	+0.696	<.001	<.001	3	4
GBM	CDKN1C →	+1.038	+0.781	<.001	<.001	3	4
BRCA	SEL1L →	-0.578	-0.642	.002	<.001	3	4
GBM	NCS1 →	+0.800	+0.887	<.001	<.001	3	4
GBM	GAL3ST1 →	+0.753	+0.660	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060074 vs AP3B2 — UCEC

Explore this scatter interactively →