Synapse maturation

Across TCGA cell cohorts, RNA activity of the Synapse maturation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYFIP2, GCH1, and TADA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYFIP2 grouped by Synapse maturation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CYFIP2 →	+1.680	+0.789	<.001	.007	3	5
LIVER	GCH1 →	+1.785	+1.338	<.001	.002	3	4
STOMACH	TADA1 →	+0.665	+1.192	.001	.007	3	4
LIVER	DNMT3A →	+1.789	+1.434	.001	<.001	3	4
LIVER	APOL3 →	-1.525	-1.285	.006	.005	3	4
LIVER	AR →	-1.333	-1.454	.009	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYFIP2 by Synapse maturation activity — LARGE_INTESTINE

Explore this box plot interactively →