Vagina development

Across TCGA patient cohorts, RNA activity of the Vagina development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNMT1, KLHDC2, and LRP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vagina development activity versus DNMT1 in CCRCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DNMT1 →	-0.236	-0.248	.005	.003	3	4
CCRCC	KLHDC2 →	+0.507	+0.461	<.001	.001	3	4
CCRCC	LRP2 →	+1.820	+0.396	<.001	<.001	3	4
LUAD	SOAT1 →	-0.332	-0.383	<.001	.007	3	4
LSCC	NAPSA →	+2.144	+0.653	<.001	.001	3	4
GBM	CTSL →	+0.821	+0.515	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060068 vs DNMT1 — CCRCC

Explore this scatter interactively →