Uterus development

Across TCGA patient cohorts, RNA activity of the Uterus development pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF3-AS1, TET1, and LZTFL1, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Uterus development activity versus KLF3-AS1 in ACC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	KLF3-AS1 →	+0.924	+0.073	<.001	<.001	3	20
SARC	TET1 →	+0.765	+0.055	<.001	<.001	3	19
UCS	LZTFL1 →	+0.730	+0.067	.003	.003	2	20
LAML	HOXA6 →	+1.842	+0.057	<.001	<.001	3	19
ACC	WNT5A →	+1.762	+0.089	<.001	<.001	3	19
KIRP	MSANTD2 →	+0.792	+0.057	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060065 vs KLF3-AS1 — ACC

Explore this scatter interactively →