Mammary gland involution

Across TCGA patient cohorts, RNA activity of the Mammary gland involution pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS3, NKTR, and ZYX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland involution activity versus PLS3 in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLS3 →	+0.647	+0.108	<.001	<.001	3	8
LSCC	NKTR →	-0.251	-0.093	.001	<.001	3	7
LSCC	ZYX →	+0.327	+0.096	<.001	<.001	3	7
OV	CNN2 →	+0.541	+0.067	.003	.001	3	7
UCEC	FILIP1L →	+0.624	+0.069	<.001	<.001	3	7
OV	FLNA →	+0.613	+0.098	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060056 vs PLS3 — LUAD

Explore this scatter interactively →