Mammary gland involution

Across TCGA cell cohorts, RNA activity of the Mammary gland involution pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC29A4, VPS37C, and SOX12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC29A4 grouped by Mammary gland involution-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC29A4 →	+1.312	+0.960	<.001	<.001	3	4
BLOOD_Lymphoma	VPS37C →	+0.920	+2.029	.002	<.001	3	4
KIDNEY	SOX12 →	+0.931	+0.940	<.001	<.001	3	4
STOMACH	CARD10 →	-1.455	-1.352	.007	.005	3	4
STOMACH	TP53BP1 →	+0.777	+1.279	.006	.001	3	4
SKIN	GSN →	-0.811	-0.558	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC29A4 by Mammary gland involution activity — BREAST

Explore this box plot interactively →