Mammary gland involution

Across TCGA cell cohorts, RNA activity of the Mammary gland involution pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV1, CLDN1, and NFKB1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland involution activity versus CAV1 in SOFT_TISSUE (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CAV1 →	+5.209	+0.276	<.001	<.001	3	12
OESOPHAGUS	CLDN1 →	+3.158	+0.157	<.001	.001	3	11
BLOOD_Leukemia	NFKB1 →	+1.126	+0.387	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	IRF1 →	+1.920	+0.137	<.001	.003	3	11
OESOPHAGUS	CTSS →	+2.871	+0.173	<.001	.001	3	10
URINARY_TRACT	ITGB6 →	+3.842	+0.136	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060056 vs CAV1 — SOFT_TISSUE

Explore this scatter interactively →