Angiogenesis involved in wound healing

Across TCGA patient cohorts, RNA activity of the Angiogenesis involved in wound healing pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGF, DENND2A, and GLI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Angiogenesis involved in wound healing activity versus NGF in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NGF →	+0.543	+0.874	.003	.001	3	4
UCEC	DENND2A →	+0.748	+0.975	.001	<.001	3	4
LSCC	GLI2 →	+0.854	+0.323	<.001	<.001	3	4
BRCA	KCNJ2-AS1 →	+0.186	+0.400	.009	.008	2	5
UCEC	TSHZ3 →	+1.133	+1.072	<.001	<.001	2	4
UCEC	HOXD10 →	+0.978	+1.099	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060055 vs NGF — UCEC

Explore this scatter interactively →