Angiogenesis involved in wound healing

Across TCGA cell cohorts, RNA activity of the Angiogenesis involved in wound healing pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPM2, ZNF581, and RAB11FIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPM2 grouped by Angiogenesis involved in wound healing-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DPM2 →	-0.661	-1.371	.003	.001	3	4
SOFT_TISSUE	ZNF581 →	+0.981	+1.605	<.001	<.001	3	4
BLOOD_Leukemia	RAB11FIP1 →	+1.241	+0.761	.003	.008	2	5
KIDNEY	ZKSCAN2 →	+0.573	+1.020	.009	.005	3	3
SOFT_TISSUE	ISYNA1 →	+3.431	+1.217	.005	.005	3	3
SOFT_TISSUE	TMEM135 →	+1.195	+1.148	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPM2 by Angiogenesis involved in wound healing activity — SOFT_TISSUE

Explore this box plot interactively →