Angiogenesis involved in wound healing

Across TCGA cell cohorts, RNA activity of the Angiogenesis involved in wound healing pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX16, CAMKK2, and CCDC148, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Angiogenesis involved in wound healing activity versus SNX16 in KIDNEY (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SNX16 →	+1.098	+0.384	.002	.001	3	4
BONE	CAMKK2 →	-1.710	-1.718	<.001	<.001	2	5
CNS	CCDC148 →	+0.520	+0.800	.003	.008	3	4
LUNG_NSCLC_LUAD	KCNK1 →	-1.791	-1.158	.009	.001	3	4
LUNG_NSCLC_LUAD	C1orf116 →	-1.779	-0.956	.008	.002	3	4
LUNG_NSCLC_LUAD	TXNIP →	-1.861	-0.783	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060055 vs SNX16 — KIDNEY

Explore this scatter interactively →