Positive regulation of epithelial cell proliferation involved in wound healing

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in wound healing pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NECAP1, THEMIS2, and TNFAIP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell proliferation involved in wound healing activity versus NECAP1 in LUAD (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NECAP1 →	-0.147	-0.047	.001	<.001	3	6
GBM	THEMIS2 →	+0.432	+0.116	<.001	.005	3	5
GBM	TNFAIP8 →	+0.849	+0.135	<.001	<.001	3	5
BRCA	HECTD4 →	-0.306	-0.083	<.001	<.001	3	5
LUAD	BTK →	+0.316	+0.078	.001	<.001	3	5
GBM	ALOX5 →	+0.620	+0.158	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060054 vs NECAP1 — LUAD

Explore this scatter interactively →