Positive regulation of epithelial cell proliferation involved in wound healing

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL38, ADIG, and RAPGEF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL38 grouped by Positive regulation of epithelial cell proliferation involved in wound healing-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL38 →	-0.491	-2.069	.004	<.001	2	6
LUNG_NSCLC_LUSC	ADIG →	-0.157	-1.403	<.001	.001	3	4
LUNG_SCLC	RAPGEF1 →	+0.324	+1.692	.001	.001	3	4
BLOOD_Leukemia	WNT8A →	-0.397	-1.684	.001	.003	3	4
LUNG_SCLC	ACVR1B →	-0.198	-1.986	.003	<.001	3	3
BREAST	FEN1 →	-0.155	-1.135	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL38 by Positive regulation of epithelial cell proliferation involved in wound healing activity — BLOOD_Lymphoma

Explore this box plot interactively →