Neurofilament cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Neurofilament cytoskeleton organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD1, NEFH, and INA, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOD1 grouped by Neurofilament cytoskeleton organization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SOD1 →	-0.686	-0.432	<.001	.003	3	11
BREAST	NEFH →	-0.326	-0.581	<.001	<.001	3	9
BLOOD_Leukemia	INA →	-0.237	-1.093	.003	.009	3	5
SOFT_TISSUE	SLC35E4 →	-0.290	-0.365	.006	<.001	3	4
BREAST	OR56B4 →	+0.333	+0.273	.005	.005	3	4
OVARY	ZNF569 →	-0.349	-0.274	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOD1 by Neurofilament cytoskeleton organization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →