Cardiac muscle contraction

Across TCGA patient cohorts, RNA activity of the Cardiac muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1A1, RRP12, and LUM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle contraction activity versus GUCY1A1 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCY1A1 →	+0.568	+0.053	<.001	<.001	3	9
LSCC	RRP12 →	-0.330	-0.032	<.001	<.001	3	9
BRCA	LUM →	+1.023	+0.030	<.001	<.001	3	9
LSCC	MCM3 →	-0.652	-0.042	<.001	<.001	3	9
OV	NAA25 →	-0.336	-0.024	<.001	<.001	3	9
OV	NID2 →	+0.591	+0.021	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060048 vs GUCY1A1 — UCEC

Explore this scatter interactively →