Cardiac muscle contraction

Across TCGA patient cohorts, RNA activity of the Cardiac muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP1, YBX3, and SERPINE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle contraction activity versus EMP1 in BRCA (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EMP1 →	+0.726	+0.361	.001	<.001	3	4
BRCA	YBX3 →	+0.622	+0.295	.004	.004	3	4
BRCA	SERPINE1 →	+0.902	+0.235	<.001	.001	3	4
BRCA	BMP1 →	+0.564	+0.193	<.001	.009	3	4
BRCA	LAMB3 →	+0.917	+0.225	.001	.002	3	4
LSCC	FGF1 →	+1.055	+0.406	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060048 vs EMP1 — BRCA

Explore this scatter interactively →