Negative regulation of cardiac muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPSAP60, SLC29A3, and SLC30A10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle cell proliferation activity versus RPSAP60 in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPSAP60 →	+0.338	+0.502	<.001	.003	3	3
OV	SLC29A3 →	-0.399	-0.231	.001	.002	3	3
COAD	SLC30A10 →	-0.209	-0.561	.006	.004	3	3
COAD	SIAH2-AS1 →	-0.108	-0.677	.001	<.001	3	3
GBM	FA2H →	-0.995	-0.818	.006	<.001	3	3
LUAD	HBP1 →	+0.272	+0.670	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060044 vs RPSAP60 — HNSC

Explore this scatter interactively →