Regulation of cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPA, TMED10, and TWNK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell proliferation activity versus SNRPA in BREAST (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SNRPA →	+0.371	+1.018	.003	<.001	3	6
LUNG_NSCLC_LUAD	TMED10 →	-0.885	-0.968	.001	<.001	3	6
LIVER	TWNK →	+0.879	+1.830	.006	<.001	3	5
LIVER	LSM12 →	+0.752	+1.643	.001	<.001	3	5
LIVER	SAAL1 →	+0.642	+1.610	.006	.001	3	5
LIVER	TAF15 →	+1.104	+1.472	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060043 vs SNRPA — BREAST

Explore this scatter interactively →