Regulation of cardiac muscle cell proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cardiac muscle cell proliferation pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 46 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of cardiac muscle cell proliferation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and HNSC, show the opposite pattern, with higher activity associated with better survival.

UVM, ACC, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.717	0.390	.001	65	view →
ACC	OS	Tertile	IV	0.247	0.777	<.001	55	view →
DLBC	DFS	Median	II,III,IV	0.562	0.950	.003	30	view →
KIRP	OS	Median	III,IV	0.238	0.608	.001	29	view →
KIRC	OS	Median	II,III,IV	0.444	0.625	.002	28	view →
HNSC	DFS	Tertile	IV	0.626	0.454	.002	28	view →
LGG	OS	Quartile	All	0.984	0.822	<.001	23	view →
LIHC	DFS	Median	III,IV	0.608	0.248	.003	23	view →
PAAD	OS	Quartile	All	0.470	0.809	<.001	21	view →
UCEC	DFS	Median	II,III,IV	0.881	0.762	.004	20	view →
UCS	DFS	Tertile	II,III,IV	0.501	0.103	.012	18	view →
COAD	OS	Quartile	IV	0.353	0.816	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0060043–UVM (DFS)

Open the UVM breakdown →