Retina morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Retina morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARF6, PDE2A, and PPP2R1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina morphogenesis in camera-type eye activity versus ARF6 in GBM (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARF6 →	-0.241	-0.495	.007	.003	3	4
GBM	PDE2A →	+0.615	+0.398	.002	.004	3	4
GBM	PPP2R1A →	+0.197	+0.551	.001	<.001	3	3
LUAD	HSPB1 →	-0.604	-0.596	.003	.002	3	3
GBM	KCNT1 →	+0.469	+0.421	.003	.002	3	3
LUAD	ETF1 →	-0.350	-0.634	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060042 vs ARF6 — GBM

Explore this scatter interactively →