Cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GYPC, PKN1, and ARPP19, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell proliferation activity versus GYPC in CNS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GYPC →	+4.199	+0.480	<.001	.007	3	3
LARGE_INTESTINE	PKN1 →	-1.290	-0.564	.007	.004	3	2
LARGE_INTESTINE	ARPP19 →	-0.919	-0.570	.001	.004	3	2
LARGE_INTESTINE	CALML4 →	+1.594	+0.572	.003	.006	3	2
LARGE_INTESTINE	NDEL1 →	-0.604	-0.535	.003	.008	3	2
LARGE_INTESTINE	ASTL →	+0.376	+0.446	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060038 vs GYPC — CNS

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