Convergent extension

Across TCGA patient cohorts, RNA activity of the Convergent extension pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP1, PTK7, and CASP10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Convergent extension activity versus SFRP1 in LSCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SFRP1 →	+1.058	+0.078	<.001	<.001	3	7
COAD	PTK7 →	+0.671	+0.076	<.001	<.001	3	7
LSCC	CASP10 →	-0.280	-0.055	.005	<.001	3	7
BRCA	DENND2D →	-0.364	-0.036	<.001	.001	3	7
OV	COL5A1 →	+0.952	+0.064	<.001	<.001	3	6
PDAC	IGFBP7 →	+0.508	+0.053	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060026 vs SFRP1 — LSCC

Explore this scatter interactively →