Convergent extension

Across TCGA cell cohorts, RNA activity of the Convergent extension pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOLH1, ADAM15, and FMNL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOLH1 grouped by Convergent extension-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FOLH1 →	-0.150	-0.191	.003	.002	3	3
KIDNEY	ADAM15 →	-0.213	-0.135	.006	.002	3	3
LUNG_NSCLC_LUAD	FMNL2 →	+0.149	+0.583	.004	.003	3	3
LUNG_NSCLC_LUAD	H2AC20 →	-0.133	-0.738	<.001	.005	3	3
BLOOD_Myeloma	PCDHB7 →	-0.219	-0.191	<.001	.002	3	3
CNS	OR4K13 →	-0.288	-0.157	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOLH1 by Convergent extension activity — BLOOD_Myeloma

Explore this box plot interactively →