Righting reflex

pathway activity — cross-omics
GO:0060013Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Righting reflex pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP4_S696, ALDH1A3, and ARHGAP32_S682, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADMAP4_S696 →-0.796-0.081<.001<.00136
OVALDH1A3 →+0.899+0.053.003.00827
UCECARHGAP32_S682 →+0.383+0.103<.001<.00136
BRCAARHGEF37 →+0.446+0.063<.001.00436
BRCAWIZ →-0.212-0.064.001.00136
CCRCCDTX3L_S539 →-0.389-0.069.001.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration