Righting reflex

pathway activity — cross-omics
GO:0060013Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Righting reflex pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YPEL2, RPL21, and RRAS, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECYPEL2 →+1.228+0.545.001<.00133
OVRPL21 →-0.485-0.802<.001<.00133
COADRRAS →+0.520+0.118.001.00533
OVZC3H14_S620 →-0.892-0.588<.001<.00133
OVCES1 →+1.114+0.770<.001<.00133
COADCNRIP1 →+0.667+0.191<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration