"Synaptic transmission, glycinergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, glycinergic" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD36, ANKRD35_S762, and PLIN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, glycinergic" activity versus CD36 in UCEC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD36 →	-0.953	-0.497	<.001	<.001	3	5
OV	ANKRD35_S762 →	+1.123	+0.097	.003	.001	2	6
UCEC	PLIN3 →	+0.243	+0.290	.009	.009	3	3
HNSC	USP8 →	+0.117	+0.340	.005	.001	3	3
UCEC	ZFC3H1 →	-0.188	-0.372	<.001	<.001	3	3
UCEC	CASP6 →	+0.406	+0.356	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060012 vs CD36 — UCEC

Explore this scatter interactively →