"Synaptic transmission, glycinergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, glycinergic" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE6, SSTR1, and AK5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, glycinergic" activity versus CPNE6 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CPNE6 →	+0.952	+0.928	<.001	<.001	3	2
UCEC	SSTR1 →	+1.315	+0.055	.004	.008	3	2
GBM	AK5 →	+1.381	+1.014	<.001	<.001	3	2
UCEC	TM4SF1 →	-3.285	-0.039	.007	.008	3	2
UCEC	EIF4EBP1 →	-2.143	-0.039	<.001	.008	3	2
GBM	ADAP1 →	+0.495	+0.675	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060012 vs CPNE6 — GBM

Explore this scatter interactively →