Relaxation of cardiac muscle

Across TCGA patient cohorts, RNA activity of the Relaxation of cardiac muscle pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HRC, SYNPO2, and ATP1A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of cardiac muscle activity versus HRC in HNSC (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HRC →	+2.655	+0.550	<.001	<.001	3	6
HNSC	SYNPO2 →	+1.084	+0.463	<.001	<.001	3	6
GBM	ATP1A2 →	+1.760	+0.449	.001	.001	3	6
BRCA	ARHGAP6 →	+0.564	+0.364	.001	.004	3	6
GBM	ASPA →	+1.143	+0.309	<.001	.002	3	6
BRCA	PRR11 →	-0.894	-0.363	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055119 vs HRC — HNSC

Explore this scatter interactively →