Sterol homeostasis

Across TCGA patient cohorts, RNA activity of the Sterol homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, TNS2, and EHD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol homeostasis activity versus CES1 in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CES1 →	+1.002	+0.024	<.001	<.001	3	7
CCRCC	TNS2 →	+0.244	+0.021	<.001	.004	3	6
BRCA	EHD2 →	+0.671	+0.031	<.001	.001	3	6
BRCA	KANK2 →	+0.427	+0.034	.002	<.001	3	6
GBM	MTM1 →	+0.279	+0.046	<.001	<.001	3	6
OV	SEPTIN11 →	+0.307	+0.029	.005	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055092 vs CES1 — BRCA

Explore this scatter interactively →