Sterol homeostasis

Across TCGA patient cohorts, RNA activity of the Sterol homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZH2, CARD6, and IGFBP7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol homeostasis activity versus EZH2 in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EZH2 →	-0.773	-0.171	.001	.001	3	6
HNSC	CARD6 →	+0.615	+0.169	<.001	<.001	3	5
GBM	IGFBP7 →	+0.822	+0.150	<.001	.004	3	5
OV	PDPN →	+0.938	+0.194	.004	<.001	3	5
OV	SMIM3 →	+0.765	+0.128	<.001	.005	3	5
BRCA	CAVIN1 →	+0.837	+0.169	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055092 vs EZH2 — GBM

Explore this scatter interactively →