Fatty acid homeostasis

Across TCGA patient cohorts, RNA activity of the Fatty acid homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLXNB2, CHD7_S2956, and CDKAL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid homeostasis activity versus PLXNB2 in UCEC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLXNB2 →	-0.192	-0.064	.003	.003	3	5
LUAD	CHD7_S2956 →	+0.664	+0.055	<.001	<.001	3	5
LUAD	CDKAL1 →	+0.245	+0.060	<.001	<.001	3	5
UCEC	GNAQ →	-0.256	-0.061	.005	.002	2	5
COAD	NONO →	+0.142	+0.042	<.001	.002	3	4
BRCA	ERGIC1 →	-0.701	-0.039	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055089 vs PLXNB2 — UCEC

Explore this scatter interactively →